This course is a theoretical and practical training on the recently emerged field of neuroepigenetics. It will provide an overview of the current concepts and knowledge on the nature and functions of the epigenome in the nervous system, its modes of regulation and its link to brain health and disease. It will combine lectures and hands-on projects to learn about state-of-the-art approaches and methodologies to study how the epigenome is established and modulated by behaviour in rodents and invertebrates, what machinery is involved and what is its causal relationship to functions. It will include methods in behaviour, epigenetics, (epi)genome editing, molecular and cell biology, -omics and bioinformatics.
This course wishes to foster the development of neuroepigenetics as a key discipline in the neurosciences, and train and educate young researchers expected to contribute to the field in the near future. It is intended for PhD students and early career postdocs who wish to acquire good bases and broad knowledge of the field.
Course director & co-directors
- Karine Merienne (CNRS – LNCA, University of Strasbourg, France)
- Angel Barco (Neurosciences Institute -UMH-CSIC, Spain)
- André Fischer (German Center for Neurodegenerative diseases -DZNE, Germany)
- Bartek Wilczyński (Institute of Informatics, University of Warsaw, Poland)
November 21 – 11:00am
Karine Merienne (University of Strasbourg, France)
Epigenetic gene reprogramming in Huntington’s disease.
November 22 – 6:00pm (Virtual talk)
Elisabeth Heller (University of Pennsylvania, USA)
Epigenetic editing for the study of reward pathophysiology.
November 25 – 9:00am (Virtual talk)
Elisabeth Binder (Max Planck Institute of Psichiatry, Germany)
Epigenetic embedding of adverse life events.
November 25 – 9:45am (Virtual talk)
Diagenode : Presentation
November 26 – 9:00am
Olivia Engmann (Friedrich Schiller University Jena, Germany)
Reversing chronic stress effects through life-style interventions.
November 28 – 9:00am
Active Motif : Presentation
December 1 – 9:00am
Angel Barco (Neurosciences Institute UMH-CSIC, Spain)
Epigenetic etiology of intellectual disability.
December 2 – 9:00am
Anne-Laurence Boutillier (University of Strasbourg, France)
Acetylation dysregulations in hippocampal neurons in Alzheimer’s disease: are we looking at the right culprit ?
December 5 – 9:00am
Bartek Wilczynski (Institute of Informatics, University of Warsaw, Poland)
Using Machine Learning techniques to understand and classify epigenomic marks on promoters and enhancers.
December 6 – 9:00am
Aleksandra Pekowska (Dioscuri Center of Chromatin Biology and Epigenomics, Poland)
Molecular signature of astrocyte evolution in primates.
December 7 – 9:00am (Virtual talk)
André Fischer (German Center for Neurodegenerative diseases, Germany)
Epigenetic processes in neurodegenerative and neuropsychiatric diseases.
December 7 – 9:45am
Denes Hnisz (Max Planck Institute for Molecular Genetics, Germany)
Transcriptional condensates in health and disease.
December 7 – 5:30pm
Johannes Graff (EPFL, Switzerland)
Epigenetic priming of memory formation.
December 8 – 9:00am
Gonçalo Castelo Branco (Karolinska Institute, Sweden)
Oligodendroglia during development and disease: insights from single-cell and spatial epigenomics.
Marta Alaiz Noya – Instituto de Neurociencias UMH-CSIC, Spain
Rafael Alcala Vida – Instituto de Neurociencias UMH-CSIC, Spain
Mykhailo Batiuk – EPFL, Lausanne, Swiss
Davide Coda – EPFL, Lausanne, Swiss
Charles Decraene – LNCA, Strasbourg, France
Beatriz del Blanco Pablos – Instituto de Neurociencias UMH-CSIC, Spain
Aleksander Jankowski – Institute of informatics, Warsaw, Poland
Lalit Kaurani – DZNE, Göttingen, Germany
Marta Kullis – IDIBABS, Barcelona, Spain
Jose Lopez Atalaya – Instituto de Neurociencias UMH-CSIC, Spain
Pierre-Eric Lutz – INCI, Strasbourg, France
Magdalena Machnicka – Institute of informatics, Warsaw, Poland
Angel Marquez Galera – Instituto de Neurociencias UMH-CSIC, Spain
Isabel Paiva – LNCA, Strasbourg, France
Jose Sanchez-Mut – Instituto de Neurociencias UMH-CSIC, Spain
Sophie Schroeder – DZNE, Göttingen, Germany
Tanya Vavouri – Pujol Research Institute, Badalona, Spain
Elisabeth Binder – Max Planck Institute of Psychiatry, Munich, Germany
Anne-Laurence Boutillier – LNCA, Strasbourg, France
Goncalo Castelo Branco – Karolinska Institute, Stockholm, Sweden
Olivia Engmann – Institute for Human Genetics, Germany
Andre Fischer – German Center for Neurodegenerative diseases, Germany
Johannes Gräff – EPFL, Lausanne, Swiss
Elisabeth Heller – Penn Epigenetics Institute, Philadelphia, USA
Denes Hnisz – Max Planck Institute for Molecular Genetics, Berlin, Germany
Aleksandra Pekowska – Dioscuri Center of Chromatin Biology and Epigenomics, Poland
Thanks to Bordeaux University Platforms